Gianotti–Crosti Syndrome: Symptoms, Causes, and Treatment

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Gianotti–Crosti syndrome is a mild, self-limiting rash that typically affects children under the age of 5. The rash is characterized by small, flat, pink or red bumps that appear on the face, arms, legs, and trunk. The rash usually lasts for 2-4 weeks and does not require any treatment.


The most common symptom of Gianotti–Crosti syndrome is a rash. The rash typically starts on the face and then spreads to the arms, legs, and trunk. The bumps in the rash are small, flat, and pink or red. They may be itchy, but they are not usually painful.

Other symptoms of Gianotti–Crosti syndrome may include:

  • Fever
  • Fatigue
  • Swollen lymph nodes
  • Sore throat
  • Cough


The exact cause of Gianotti–Crosti syndrome is unknown. However, it is thought to be caused by a reaction to a viral infection. The most common viruses that are associated with Gianotti–Crosti syndrome are:

  • Epstein–Barr virus (EBV)
  • Cytomegalovirus (CMV)
  • Hepatitis B virus (HBV)
  • Hepatitis A virus (HAV)


Gianotti–Crosti syndrome does not require any treatment. The rash will usually go away on its own within 2-4 weeks. However, there are some things that you can do to help relieve the symptoms, such as:

  • Applying a cool compress to the rash
  • Taking an over-the-counter pain reliever, such as ibuprofen or acetaminophen
  • Using an oatmeal bath


There is no way to prevent Gianotti–Crosti syndrome. However, you can reduce your child's risk of getting the rash by washing their hands frequently and avoiding contact with people who are sick.


  • Gianotti–Crosti syndrome
  • Rash in children
  • Viral infection in children
  • EBV rash
  • CMV rash
  • HBV rash
  • HAV rash
  • Treatment for Gianotti–Crosti syndrome
  • Prevention of Gianotti–Crosti syndrome

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